Biocompatible C-S bond construction for diarylmethyl thioethers

Biocompatible C-S bond construction for diarylmethyl thioethers

We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thio...

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Bibliographic Details
Main Authors: Zhang, Zhenwei, Tao, Xu, Ju, Chengyang, Gao, Cuiqing, Loh, Teck-Peng, Xie, Peizhong
Other Authors: School of Chemistry, Chemical Engineering and Biotechnology
Format: Article
Language:English
Published: 2025
Subjects:
Chemistry
Bioconjugation
Biocompatible conditions
Online Access:https://hdl.handle.net/10356/184429
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Summary:We have developed a sustainable method for the construction of C-S bonds, in line with green chemistry principles, and modifiable for thiol-specific conjugation. Selecting p-quinone methides (p-QMs) as partners, this methodology allows efficient preparation of diarylmethyl thioethers with broad thiol compatibility, exceptional chemo-selectivity, and stability. This process facilitates the large-scale preparation of diarylmethyl thioethers, and also enhances applications in bioconjugation, providing valuable tools for drug development and biomolecular engineering.

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