Chromatography refolding of recombinant alpha-fetoprotein for high refolding productivity and intensified bioprocessing

• المؤلف الرئيسي: Chen, Yu
• مؤلفون آخرون: Susanna Leong Su Jan
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2011
• الموضوعات: DRNTU::Engineering::Chemical engineering::Biotechnological production
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/43987
• المؤسسة: Nanyang Technological University

Alpha-fetoprotein (AFP) is a commercially valuable biopharmaceutical candidate for autoimmune indications. Transgenically-derived recombinant AFP has recently successfully completed a Phase Two clinical trial study for rheumatoid arthritis indications at Merrimack Pharmaceuticals (Cambridge, MA, USA...