Nuclear magnetic resonance (NMR) spectroscopy of membrane and membrane associated proteins.
Biological membranes serve as essential barriers between living cells and their surroundings, as well as within the living cell, and are seen as primary targets for pharmaceutical and drug development against disease and illness. In order to understand the structure-function relationships of membran...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | |
| التنسيق: | Theses and Dissertations |
| اللغة: | English |
| منشور في: |
2013
|
| الموضوعات: | |
| الوصول للمادة أونلاين: | http://hdl.handle.net/10356/52657 |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| الملخص: | Biological membranes serve as essential barriers between living cells and their surroundings, as well as within the living cell, and are seen as primary targets for pharmaceutical and drug development against disease and illness. In order to understand the structure-function relationships of membrane proteins, high resolution three-dimensional (3D) structures are required. Nuclear magnetic resonance spectroscopy is a tool which is used to solve high resolution structures of protein.In this thesis, three membrane/ membrane associated proteins are discussed; 1) the Severe Acute Respiratory Syndrome (SARS) coronavirus envelope (E) protein, 2) the small hydrophobic (SH) protein of the human Respiratory Syncytial Virus (hRSV) and 3) the heme binding PAS domain of YybT from Geobacillus thermodenitrificans. |
|---|