Multimodal MRI-optical system for high-resolution structural and functional imaging
Near-infrared (NIR) based bioimaging modalities use electromagnetic waves in the near-infrared spectral range to study functional changes in living tissue by detecting changes in absorption, fluorescence, or scatter arising from intrinsic chromophores such as oxy- and deoxyhaemoglobin, cytochromes,...
Saved in:
| 主要作者: | |
|---|---|
| 其他作者: | |
| 格式: | Final Year Project |
| 語言: | English |
| 出版: |
2015
|
| 主題: | |
| 在線閱讀: | http://hdl.handle.net/10356/65226 |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|
| 機構: | Nanyang Technological University |
| 語言: | English |
| 總結: | Near-infrared (NIR) based bioimaging modalities use electromagnetic waves in the near-infrared spectral range to study functional changes in living tissue by detecting changes in absorption, fluorescence, or scatter arising from intrinsic chromophores such as oxy- and deoxyhaemoglobin, cytochromes, metabolites etc. while Magnetic Resonance Imaging provides superior soft tissue contrast which makes it the ideal imaging modality for non-invasive visualization of brain architecture. Integrating the two modalities then creates a dual-mode imaging system that combines in vivomolecular and functional imagingwith high-quality anatomic imaging.
In this research project, we set up the NIR optical setup and then worked on integrating it with the MRI scanner for simultaneous in-vivo imaging. Setup included aligning and fine-tuning the optical and electronic components as well as developing a LabVIEW based software platform to interface with each component and acquire images. The system was calibrated using DIY gelatin-based tissue phantoms for preliminary image acquisition. |
|---|