Fragment-based drug discovery and mechanistic studies of human thymidylate synthase

Fragment-based drug discovery and mechanistic studies of human thymidylate synthase

Human thymidylate synthase (hTS) is the sole enzyme responsible for de novo biosynthesis of dTMP and is vital to cell proliferation and survival. Inhibition of hTS has been explored and found to be effective in cancer chemotherapy, while the efficacy is limited by drug resistance. Herein fragment sc...

Saved in:

書目詳細資料
主要作者:	Chen, Dan
其他作者:	-
格式:	Thesis-Doctor of Philosophy
語言:	English
出版:	Nanyang Technological University 2016
主題:	DRNTU::Science::Biological sciences::Molecular biology
在線閱讀:	https://hdl.handle.net/10356/65932
標簽:	添加標簽沒有標簽, 成為第一個標記此記錄!

相似書籍

Subunit Complementation of Thymidylate Synthase
由: Manee Pookanjanatavip, et al.
出版: (2018)

Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase
由: Manee Chanama, et al.
出版: (2018)

CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
由: Almqvist, Helena, et al.
出版: (2018)

Unique structural and mechanistic properties of mycobacterial F-ATP synthases : implications for drug design
由: Kamariah, Neelagandan, et al.
出版: (2020)

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states
由: Chen, Dan, et al.
出版: (2018)

Heterologous Expression of Active Thymidylate Synthase–Dihydrofolate Reductase from Plasmodium falciparum
由: Worachart Sirawaraporn, et al.
出版: (2018)

High-performance liquid chromatographic assay for thymidylate synthase from the human malaria parasite, plasmodium falciparum
由: Jerapan Krungkrai, et al.
出版: (2018)

Chemical synthesis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene
由: Phisit Prapunwattana, et al.
出版: (2018)

Structural Insight into Effective Inhibitors' Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase
由: Jarunee Vanichtanankul, et al.
出版: (2022)

Crystallization and preliminary crystallographic studies of dihydrofolate reductase-thymidylate synthase from Trypanosoma cruzi, the Chagas disease pathogen
由: Penchit Chitnumsub, et al.
出版: (2018)

Effect of N-terminal truncation of Plasmodium falciparum dihydrofolate reductase on dihydrofolate reductase and thymidylate synthase activity
由: Jantanee Wattanarangsan, et al.
出版: (2018)

Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum
由: Penchit Chitnumsub, et al.
出版: (2018)

Linker prediction in fragment-based drug design.
由: Nyam, Ching Wee.
出版: (2011)

Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: Structural basis for antifolate resistance and development of effective inhibitors
由: Y. Yuthavong, et al.
出版: (2018)

Mechanistic insights into kindlin function and regulation
由: Levitskaya, Zarina
出版: (2022)

The role of N157 of A-ATP synthase subunit B in nucleotide binding and expression, production and structural and mechanistic features of subunits α and ε of Mycobacterium tuberculosis F-ATP synthase
由: Sundararaman, Lavanya
出版: (2016)

Comparative studies on thymidylate synthetase from P. berghei and mouse reticulocytes
由: Sa Nga Pattanakitsakul, et al.
出版: (2018)

Structural characterization of iterative polyketide synthases
由: Tan, Jackie Yen
出版: (2021)

Effects of thrombin and its related peptide fragments on neutrophils
由: Lim, Chun Hwee
出版: (2018)

The molecular motor F-ATP synthase is targeted by the tumoricidal protein HAMLET
由: Ho, James, et al.
出版: (2015)

Mechanistic action of weak acid drugs on biofilms
由: Kundukad, Binu, et al.
出版: (2018)

Understanding the viral protein structures of clinically relevant arboviruses and fragment-based screening for antivirals
由: Farhana Abu Bakar
出版: (2020)

Insights into the programmed ketoreduction of partially reducing polyketide synthases : stereo- and substrate-specificity of the ketoreductase domain
由: Soehano, Ishin, et al.
出版: (2015)

System biology approach for functional annotation of the genome of human malaria parasite plasmodium falciparum and antimalarial drug discovery
由: Naw, Wah Wah
出版: (2015)

Biomolecular function discovery through computational protein sequence analysis.
由: Sameer Abdul Jalil.
出版: (2009)

Structural studies of the nucleosome, assembled with different histones, DNA fragments and HMGN proteins, and derivatized with ruthenium anticancer agents
由: Reyhan Muhammad
出版: (2013)

Erratum: Characterization, crystallization and preliminary X-ray analysis of bifunctional dihydrofolate reductase-thymidylate synthase from Plasmodium falciparum (Acta Crystallographica Section D: Biological Crystallography (2004) D60 (780-783))
由: Penchit Chitnumsub, et al.
出版: (2018)

Genes implicated in phorbol ester (PE) biosynthesis and interception through downregulation of casbene synthase genes
由: Ng, Ailing
出版: (2014)

An inducible and reversible genetics platform for novel drug target discovery
由: Leong, Mei Ling
出版: (2019)

Oxidative phosphorylation — an update on a new, essential target space for drug discovery in mycobacterium tuberculosis
由: Foo, Caroline Shi-Yan, et al.
出版: (2020)

Biomolecular function discovery through computational protein sequence analysis : project 2
由: Neo, Keng Hwee
出版: (2009)

Drug discovery: repurposin drug for antifungal treatment targeting novel pathway
由: Png, Zheng Long
出版: (2023)

Drug discovery to reverse clarithromycin resistance in multidrug-resistant mycobacterium abscessus
由: Dam, Linh Chi
出版: (2019)

Fragment screening for stabilizers and binders to human DJ-1
由: Oh, Xu Xuan
出版: (2016)

Trail of nucleotides and the traits of ADP/ATP-binding inside the subunits A and B of the archaeal energy producer A1AO ATP synthase
由: Kumar, Anil
出版: (2010)

Weak affinity chromatography for evaluation of stereoisomers in early drug discovery
由: Duong-Thi, M.-D., et al.
出版: (2013)

Discovery and characterization of bioactive cysteine-rich peptides in medicinal plants
由: Tang, Fan
出版: (2023)

Curved oligonucleotide constructs as human topoisomerase I inhibitors : a mechanistic study of the enzyme’s recognizing passway.
由: Zhao, Guanjia.
出版: (2010)

In silico analysis of pseudomonas cellulose synthase a
由: Supajit Sraphet, et al.
出版: (2020)

Discovery of stabilized functional mutants of human aquaporin 1
由: Soh, Miao Yi
出版: (2016)