Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies

• المؤلف الرئيسي: Mohan Rajan Pradhan
• مؤلفون آخرون: Chandra Shekhar Verma
• التنسيق: Theses and Dissertations
• اللغة: English
• منشور في: 2017
• الموضوعات: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
• الوصول للمادة أونلاين: http://hdl.handle.net/10356/69994
• المؤسسة: Nanyang Technological University

The role of intracellular water in biomolecular function is well recognized and yet quantifying this is challenging. This is largely because protein hydration is extremely sensitive to the protein surface chemistry and topology and also to the environmental conditions. This makes protein hydration...