Na, K-ATPase α3 is a death target of Alzheimer patient amyloid-β assembly

• المؤلفون الرئيسيون: Ohnishi, Takayuki, Yanazawa, Masako, Sasahara, Tomoya, Kitamura, Yasuki, Hiroaki, Hidekazu, Fukazawa, Yugo, Kii, Isao, Nishiyama, Takashi, Kakita, Akiyoshi, Takeda, Hiroyuki, Takeuchi, Akihide, Arai, Yoshie, Ito, Akane, Komura, Hitomi, Hirao, Hajime, Satomura, Kaori, Inoue, Masafumi, Muramatsu, Shin-ichi, Matsui, Ko, Tada, Mari, Sato, Michio, Saijo, Eri, Shigemitsu, Yoshiki, Sakai, Satoko, Umetsu, Yoshitaka, Goda, Natsuko, Takino, Naomi, Takahashi, Hitoshi, Hagiwara, Masatoshi, Sawasaki, Tatsuya, Iwasaki, Genji, Nakamura, Yu, Nabeshima, Yo-ichi, Teplow, David B., Hoshi, Minako
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: Abnormal protein–protein interaction in synapse; Hyperexcitotoxicity; NMR; Computational modeling; Protein-protein interaction inhibitors
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81180; http://hdl.handle.net/10220/39149
• المؤسسة: Nanyang Technological University

Neurodegeneration correlates with Alzheimer’s disease (AD) symptoms, but the molecular identities of pathogenic amyloid β-protein (Aβ) oligomers and their targets, leading to neurodegeneration, remain unclear. Amylospheroids (ASPD) are AD patient-derived 10- to 15-nm spherical Aβ oligomers that caus...