Conditional N-WASP knockout in mouse brain implicates actin cytoskeleton regulation in hydrocephalus pathology

• Main Authors: Jain, Neeraj, Lim, Lee Wei, Tan, Wei Ting, George, Bhawana, Makeyev, Eugene, Thanabalu, Thirumaran
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: Actin cytoskeleton; Hydrocephalus; N-WASP; Cilia; Astrogliosis; Cerebral ventricles
• 在線閱讀: https://hdl.handle.net/10356/81206; http://hdl.handle.net/10220/39154

Cerebrospinal fluid (CSF) is produced by the choroid plexus and moved by multi-ciliated ependymal cells through the ventricular system of the vertebrate brain. Defects in the ependymal layer functionality are a common cause of hydrocephalus. N-WASP (Neural-Wiskott Aldrich Syndrome Protein) is a brai...