Multiscale modelling of nucleosome core particle aggregation

• المؤلفون الرئيسيون: Fan, Yanping, Nordenskiöld, Lars, Lyubartsev, Alexander P, Korolev, Nikolay
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Nucleosome core particles; Chromatin compaction; Multivalent ions; Coarse-grained models; Multiscale simulations; Inverse Monte Carlo
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82785; http://hdl.handle.net/10220/40277

The nucleosome core particle (NCP) is the basic building block of chromatin. Under the influence of multivalent cations, isolated mononucleosomes exhibit a rich phase behaviour forming various columnar phases with characteristic NCP–NCP stacking. NCP stacking is also a regular element of chromatin s...