Next‐generation Gene Silencers for Cancer Immunotherapy

• المؤلف الرئيسي: Ng, Aik Seng
• مؤلفون آخرون: Navin Kumar Verma
• التنسيق: Student Research Poster
• اللغة: English
• منشور في: 2017
• الموضوعات: PD-1; Immunotherapy
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/83907; http://hdl.handle.net/10220/42843
• المؤسسة: Nanyang Technological University

In the tumor microenvironment, immune evasion entails a reciprocal interaction between cancer cells and T-cells. This leads to the inhibition of the tumor killing ability of T-cells via immune checkpoint protein interactions, mainly - PD-1/PD-L1 & CTLA-4/B7. [2nd Award]