The ciliopathy protein TALPID3/KIAA0586 acts upstream of Rab8 activation in zebrafish photoreceptor outer segment formation and maintenance

• Main Authors: Naharros, Irene Ojeda, Cristian, Flavia B., Zang, Jingjing, Gesemann, Matthias, Neuhauss, Stephan C. F., Bachmann-Gagescu, Ruxandra, Ingham, Philip William
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Ciliopathies; Photoreceptors (PRs)
• 在線閱讀: https://hdl.handle.net/10356/87542; http://hdl.handle.net/10220/45410
• 機構: Nanyang Technological University

Ciliopathies are human disorders caused by dysfunction of primary cilia, ubiquitous microtubule-based organelles involved in signal transduction. Cilia are anchored inside the cell through basal bodies (BBs), modified centrioles also acting as microtubule-organization centers. Photoreceptors (PRs) a...