Cadmium nanoparticles citrullinate cytokeratins within lung epithelial cells: cadmium as a potential cause of citrullination in chronic obstructive pulmonary disease

• Main Authors: Hutchinson, David, Müller, Judith, McCarthy, Joseph E, Gun'ko, Yurii, Verma, Navin Kumar, Bi, Xuezhi, Di Cristo, Luisana, Kickham, Laura, Movia, Dania, Prina-Mello, Adriele, Volkov, Yuri
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2018
• 主題: Cadmium; COPD
• 在線閱讀: https://hdl.handle.net/10356/87982; http://hdl.handle.net/10220/44501
• 機構: Nanyang Technological University

Objective: The objective of the study was to determine whether the cadmium-derived materials induce intracellular protein citrullination. Methods: Human A549 lung epithelial cells were exposed to cadmium in soluble and nanoparticulate forms represented by cadmium chloride (CdCl2) and cadmium oxide (...