Stapled BH3 Peptides against MCL-1 : mechanism and design using atomistic simulations

• المؤلفون الرئيسيون: Joseph, Thomas L., Lane, David P., Verma, Chandra Shekhar.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/95173; http://hdl.handle.net/10220/9289

Atomistic simulations of a set of stapled alpha helical peptides derived from the BH3 helix of MCL-1 (Stewart et al. (2010) Nat Chem Biol 6: 595–601) complexed to a fragment (residues 172–320) of MCL-1 revealed that the highest affinity is achieved when the staples engage the surface of MCL-1 as has...