Murine cd4+ T cell Responses are inhibited by cytotoxic T cell-mediated killing of dendritic cells and are restored by antigen transfer

• المؤلفون الرئيسيون: Ma, Joel Zhi-Iong, Lim, So Nai, Qin, Jim Shixiang, Yang, Jianping, Enomoto, Noriyuki, Ruedl, Christiane, Ronchese, Franca
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/95319; http://hdl.handle.net/10220/9307
• المؤسسة: Nanyang Technological University

Cytotoxic T lymphocytes (CTL) provide protection against pathogens and tumors. In addition, experiments in mouse models have shown that CTL can also kill antigen-presenting dendritic cells (DC), reducing their ability to activate primary and secondary CD8+ T cell responses. In contrast, the effects...