P53 gene targeting by homologous recombination in fish ES cells

• المؤلفون الرئيسيون: Yan, Yan, Hong, Ni, Chen, Tiansheng, Li, Mingyou, Wang, Tiansu, Guan, Guijun, Qiao, Yongkang, Chen, Songlin, Schartl, Manfred, Hong, Yunhan, Li, Chang Ming
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences::Microbiology::Microorganisms
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/96391; http://hdl.handle.net/10220/9878

Gene targeting (GT) provides a powerful tool for the generation of precise genetic alterations in embryonic stem (ES) cells to elucidate gene function and create animal models for human diseases. This technology has, however, been limited to mouse and rat. We have previously established ES cell li...