Cysteine deleted protegrin-1 (CDP-1) : anti-bacterial activity, outer-membrane disruption and selectivity
BACKGROUND: Protegin-1 (PG-1: RGGRLCYCRRRFCVCVGR-amide) assumes a rigid β-hairpin like structure that is stabilized by two disulfide bridges between Cys6-Cys15 and Cys8-Cys13. Previous studies, employing linear analogs of PG-1, with Cys to Ala mutations or modified Cys, have demonstrated that the d...
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| Main Authors: | , |
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| 格式: | Article |
| 語言: | English |
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2015
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| 在線閱讀: | https://hdl.handle.net/10356/97888 http://hdl.handle.net/10220/25656 |
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| 機構: | Nanyang Technological University |
| 語言: | English |