Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity

• المؤلفون الرئيسيون: Ho, James C. S., Rydstrom, Anna, Manimekalai, Malathy Sony Subramanian, Svanborg, Catharina, Grüber, Gerhard
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/98357; http://hdl.handle.net/10220/10905

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here...