Low resolution solution structure of HAMLET and the importance of its alpha-domains in tumoricidal activity

• Main Authors: Ho, James C. S., Rydstrom, Anna, Manimekalai, Malathy Sony Subramanian, Svanborg, Catharina, Grüber, Gerhard
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2013
• 主題: DRNTU::Science::Biological sciences
• 在線閱讀: https://hdl.handle.net/10356/98357; http://hdl.handle.net/10220/10905
• 機構: Nanyang Technological University

HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is the first member in a new family of protein-lipid complexes with broad tumoricidal activity. Elucidating the molecular structure and the domains crucial for HAMLET formation is fundamental for understanding its tumoricidal function. Here...