Purification and structural characterization of the voltage-sensor domain of the hERG potassium channel

• المؤلفون الرئيسيون: Ng, Hui Qi, Kim, Young Mee, Huang, Qiwei, Gayen, Shovanlal, Yildiz, Ahu Arslan, Yoon, Ho Sup, Sinner, Eva-Kathrin, Kang, CongBao
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2013
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/99423; http://hdl.handle.net/10220/10951

The hERG (human ether à go-go related gene) potassium channel is a voltage-gated potassium channel playing important roles in the heart by controlling the rapid delayed rectifier potassium current. The hERG protein contains a voltage-sensor domain (VSD) that is important for sensing voltage changes...