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  _  __     ___     _    _    _    _    __   __  
 | |/ //   / _ \\  | \  / || | || | ||  \ \\/ // 
 | ' //   / //\ \\ |  \/  || | || | ||   \   //  
 | . \\  |  ___  ||| .  . || | \\_/ ||   / . \\  
 |_|\_\\ |_||  |_|||_|\/|_||  \____//   /_//\_\\ 
 `-` --` `-`   `-` `-`  `-`    `---`    `-`  --`

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Text this: During negative regulation of the human papillomavirus-16 E6 promoter, the viral E2 protein can displace Sp1 from a proximal promoter element