Sustained release of an Anti-Glaucoma drug: Demonstration of efficacy of a liposomal formulation in the rabbit eye

• Main Authors: Natarajan J.V., Chattopadhyay S., Ang M., Darwitan A., Foo S., Zhen M., Koo M., Wong T.T., Venkatraman S.S.
• Other Authors: DEAN'S OFFICE (DUKE-NUS MEDICAL SCHOOL)
• Format: Article
• Published: 2019
• Subjects: antiglaucoma agent; dipalmitoylphosphatidylcholine; drug carrier; latanoprost; liposome; antihypertensive agent; prostaglandin F; animal experiment; animal tissue; article; concentration (parameters); controlled study; differential scanning calorimetry; drug delivery system; drug dosage form comparison; drug efficacy; drug storage; female; in vitro study; lipid bilayer; molecular stability; nonhuman; rabbit; sustained release formulation; animal; chemistry; conjunctiva; delayed release formulation; drug effect; glaucoma; methodology; topical drug administration; Oryctolagus cuniculus; 1,2-Dipalmitoylphosphatidylcholine; Administration, Topical; Animals; Antihypertensive Agents; Calorimetry, Differential Scanning; Conjunctiva; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; Glaucoma; Lipid Bilayers; Liposomes; Prostaglandins F, Synthetic; Rabbits
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/162033

10.1371/journal.pone.0024513