Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

• Main Authors: Rai P., He F., Kwang J., Engelward B.P., Chow V.T.K.
• Other Authors: MICROBIOLOGY AND IMMUNOLOGY
• Format: Article
• Published: Nature Publishing Group 2020
• Subjects: ATM protein; bacterial protein; DNA dependent protein kinase; H2AFX protein, human; histone; MDC1 protein, human; nuclear protein; plY protein, Streptococcus pneumoniae; PRKDC protein, human; recombinant protein; streptolysin; TP53BP1 protein, human; transactivator protein; tumor suppressor p53 binding protein 1; A-549 cell line; cell cycle checkpoint; confocal microscopy; DNA damage; double stranded DNA break; drug effects; genetics; human; metabolism; phosphorylation; Streptococcus pneumoniae; Western blotting; A549 Cells; Ataxia Telangiectasia Mutated Proteins; Bacterial Proteins; Blotting, Western; Cell Cycle Checkpoints; DNA Breaks, Double-Stranded; DNA Damage; DNA-Activated Protein Kinase; Histones; Humans; Microscopy, Confocal; Nuclear Proteins; Phosphorylation; Recombinant Proteins; Streptolysins; Trans-Activators; Tumor Suppressor p53-Binding Protein 1
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/174979
• Institution: National University of Singapore

10.1038/srep22972