Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

10.18632/oncotarget.4956

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Main Authors:	Goh, A.M, Xue, Y, Leushacke, M, Li, L, Wong, J.S, Chiam, P.C, Binte Rahmat, S.A, Mann, M.B, Mann, K.M, Barker, N, Lozano, G, Terzian, T, Lane, D.P
Other Authors:	BIOCHEMISTRY
Format:	Article
Published:	Impact Journals LLC 2020
Subjects:	Lgr5 protein protein MDM2 protein p53 stem cell factor unclassified drug enzyme inhibitor Mdm2 protein, mouse animal cell animal tissue Article cell cycle cell differentiation cell proliferation controlled study crypt cell DNA damage down regulation gene dosage gene expression genotype immunoreactivity in vitro study ionizing radiation mouse nonhuman protein degradation protein depletion protein expression protein induction protein metabolism radiation dose 129 mouse age animal antagonists and inhibitors C57BL mouse diagnostic imaging drug effects gene expression regulation genetics knockout mouse metabolism mutation phenotype radiography small intestine time factor tissue culture technique Age Factors Animals Cell Cycle Cell Differentiation Cell Proliferation DNA Damage Enzyme Inhibitors Gene Expression Regulation Genotype Intestine, Small Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Proto-Oncogene Proteins c-mdm2 Radiography Time Factors Tissue Culture Techniques Tumor Suppressor Protein p53
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/177759
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1777592024-05-08T09:51:19Z Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice Goh, A.M Xue, Y Leushacke, M Li, L Wong, J.S Chiam, P.C Binte Rahmat, S.A Mann, M.B Mann, K.M Barker, N Lozano, G Terzian, T Lane, D.P BIOCHEMISTRY MEDICINE Lgr5 protein protein MDM2 protein p53 stem cell factor unclassified drug enzyme inhibitor Mdm2 protein, mouse protein MDM2 protein p53 animal cell animal tissue Article cell cycle cell differentiation cell proliferation controlled study crypt cell DNA damage down regulation gene dosage gene expression genotype immunoreactivity in vitro study ionizing radiation mouse nonhuman protein degradation protein depletion protein expression protein induction protein metabolism radiation dose 129 mouse age animal antagonists and inhibitors C57BL mouse diagnostic imaging drug effects gene expression regulation genetics knockout mouse metabolism mutation phenotype radiography small intestine time factor tissue culture technique Age Factors Animals Cell Cycle Cell Differentiation Cell Proliferation DNA Damage Enzyme Inhibitors Gene Expression Regulation Genotype Intestine, Small Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Proto-Oncogene Proteins c-mdm2 Radiography Time Factors Tissue Culture Techniques Tumor Suppressor Protein p53 10.18632/oncotarget.4956 Oncotarget 6 20 17968-17980 2020-10-20T03:15:37Z 2020-10-20T03:15:37Z 2015 Article Goh, A.M, Xue, Y, Leushacke, M, Li, L, Wong, J.S, Chiam, P.C, Binte Rahmat, S.A, Mann, M.B, Mann, K.M, Barker, N, Lozano, G, Terzian, T, Lane, D.P (2015). Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget 6 (20) : 17968-17980. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.4956 19492553 https://scholarbank.nus.edu.sg/handle/10635/177759 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Impact Journals LLC Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	Lgr5 protein protein MDM2 protein p53 stem cell factor unclassified drug enzyme inhibitor Mdm2 protein, mouse protein MDM2 protein p53 animal cell animal tissue Article cell cycle cell differentiation cell proliferation controlled study crypt cell DNA damage down regulation gene dosage gene expression genotype immunoreactivity in vitro study ionizing radiation mouse nonhuman protein degradation protein depletion protein expression protein induction protein metabolism radiation dose 129 mouse age animal antagonists and inhibitors C57BL mouse diagnostic imaging drug effects gene expression regulation genetics knockout mouse metabolism mutation phenotype radiography small intestine time factor tissue culture technique Age Factors Animals Cell Cycle Cell Differentiation Cell Proliferation DNA Damage Enzyme Inhibitors Gene Expression Regulation Genotype Intestine, Small Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Proto-Oncogene Proteins c-mdm2 Radiography Time Factors Tissue Culture Techniques Tumor Suppressor Protein p53
spellingShingle	Lgr5 protein protein MDM2 protein p53 stem cell factor unclassified drug enzyme inhibitor Mdm2 protein, mouse protein MDM2 protein p53 animal cell animal tissue Article cell cycle cell differentiation cell proliferation controlled study crypt cell DNA damage down regulation gene dosage gene expression genotype immunoreactivity in vitro study ionizing radiation mouse nonhuman protein degradation protein depletion protein expression protein induction protein metabolism radiation dose 129 mouse age animal antagonists and inhibitors C57BL mouse diagnostic imaging drug effects gene expression regulation genetics knockout mouse metabolism mutation phenotype radiography small intestine time factor tissue culture technique Age Factors Animals Cell Cycle Cell Differentiation Cell Proliferation DNA Damage Enzyme Inhibitors Gene Expression Regulation Genotype Intestine, Small Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Mutation Phenotype Proto-Oncogene Proteins c-mdm2 Radiography Time Factors Tissue Culture Techniques Tumor Suppressor Protein p53 Goh, A.M Xue, Y Leushacke, M Li, L Wong, J.S Chiam, P.C Binte Rahmat, S.A Mann, M.B Mann, K.M Barker, N Lozano, G Terzian, T Lane, D.P Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
description	10.18632/oncotarget.4956
author2	BIOCHEMISTRY
author_facet	BIOCHEMISTRY Goh, A.M Xue, Y Leushacke, M Li, L Wong, J.S Chiam, P.C Binte Rahmat, S.A Mann, M.B Mann, K.M Barker, N Lozano, G Terzian, T Lane, D.P
format	Article
author	Goh, A.M Xue, Y Leushacke, M Li, L Wong, J.S Chiam, P.C Binte Rahmat, S.A Mann, M.B Mann, K.M Barker, N Lozano, G Terzian, T Lane, D.P
author_sort	Goh, A.M
title	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
title_short	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
title_full	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
title_fullStr	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
title_full_unstemmed	Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice
title_sort	mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 r172h mutant mice
publisher	Impact Journals LLC
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/177759
_version_	1800914456074518528

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice

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