The chromatin remodeling factor CHD7 controls cerebellar development by regulating reelin expression

• Main Authors: Whittaker, D.E, Riegman, K.L.H, Kasah, S, Mohan, C, Yu, T, Sala, B.P, Hebaishi, H, Caruso, A, Marques, A.C, Michetti, C, Smachetti, M.E.S, Shah, A, Sabbioni, M, Kulhanci, O, Tee, W.-W, Reinberg, D, Scattoni, M.L, Volk, H, McGonnell, I, Wardle, F.C, Fernandes, C, Basson, M.A
• Other Authors: PHYSIOLOGY
• Format: Article
• Published: American Society for Clinical Investigation 2020
• Subjects: caspase; reelin; Chd7 protein, mouse; DNA binding protein; nerve cell adhesion molecule; nerve protein; reelin protein; scleroprotein; serine proteinase; animal cell; animal experiment; animal model; animal tissue; Article; brain development; BrdU assay; cell differentiation; cell proliferation; cell survival; cerebellum; cerebellum hypoplasia; CHD7 gene; chromatin assembly and disassembly; chromatin immunoprecipitation; controlled study; developmental disorder; experimental behavioral test; female; gene; gene expression; gene mutation; immunohistochemistry; in situ hybridization; male; motor coordination; motor dysfunction; mouse; nonhuman; polymerase chain reaction; protein expression; reelin gene; Western blotting; abnormalities; animal; embryology; gene expression regulation; gene locus; genetics; genome-wide association study; human; metabolism; nervous system development; nervous system malformation; neural stem cell; transgenic mouse; Animals; Cell Adhesion Molecules, Neuronal; Cerebellum; Developmental Disabilities; DNA-Binding Proteins; Extracellular Matrix Proteins; Gene Expression Regulation, Developmental; Genetic Loci; Genome-Wide Association Study; Humans; Mice; Mice, Transgenic; Motor Disorders; Nerve Tissue Proteins; Nervous System Malformations; Neural Stem Cells; Neurogenesis; Serine Endopeptidases
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/179226
• Institution: National University of Singapore

10.1172/JCI83408