N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway
10.3389/fphar.2018.01125
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Published: |
2020
|
| Subjects: | |
| Online Access: | https://scholarbank.nus.edu.sg/handle/10635/181171 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | National University of Singapore |
| id |
sg-nus-scholar.10635-181171 |
|---|---|
| record_format |
dspace |
| spelling |
sg-nus-scholar.10635-1811712023-11-01T08:15:24Z N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway Mohan, C.D Bharathkumar, H Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, S Shanmugam, M.K Chinnathambi, A Alharbi, S.A Alahmadi, T.A Bhattacharjee, A Lobie, P.E Deivasigamani, A Hui, K.M Sethi, G Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, K.S Kumar, A.P DEPT OF PHARMACOLOGY 2 [3 (3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)propyl]isoindoline 1,3 dione 4 (2,6 dichlorobenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 isopropylbenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 nitrobenzyl) 2h pyrido [3,2 b][1,4]oxazin 3(4h) one 4 (cyclohexylmethyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)methyl]benzonitrile 4 [(6,6 dimethyl 4 phenyl 5,6 dihydro 4h 1,2 oxazin 3 yl)methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [4 (tert butyl)benzyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [[4 (4 chlorophenyl) 6,6 dimethyl 5,6 dihydro 4h 1,2 oxazin 3 yl]methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4' [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3H) yl)methyl] [1,10 biphenyl] 2 carbonitrile antineoplastic agent DNA immunoglobulin enhancer binding protein liver protective agent luciferase transcription factor RelA unclassified drug animal experiment animal model animal tissue antiproliferative activity apoptosis Article cancer inhibition cell viability computer model controlled study dose response down regulation drug effect drug efficacy drug identification drug potency drug synthesis female gene expression regulation HCCLM3 cell line Hep-G2 cell line Huh-7 cell line IC50 liver cell carcinoma luciferase gene molecularly targeted therapy mouse nonhuman pharmacological parameters protein DNA binding protein expression protein phosphorylation time dependence tumor volume 10.3389/fphar.2018.01125 Frontiers in Pharmacology 9 NOV 1125 2020-10-27T10:04:52Z 2020-10-27T10:04:52Z 2018 Article Mohan, C.D, Bharathkumar, H, Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India, Rangappa, S, Shanmugam, M.K, Chinnathambi, A, Alharbi, S.A, Alahmadi, T.A, Bhattacharjee, A, Lobie, P.E, Deivasigamani, A, Hui, K.M, Sethi, G, Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India, Rangappa, K.S, Kumar, A.P (2018). N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway. Frontiers in Pharmacology 9 (NOV) : 1125. ScholarBank@NUS Repository. https://doi.org/10.3389/fphar.2018.01125 16639812 https://scholarbank.nus.edu.sg/handle/10635/181171 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Unpaywall 20201031 |
| institution |
National University of Singapore |
| building |
NUS Library |
| continent |
Asia |
| country |
Singapore Singapore |
| content_provider |
NUS Library |
| collection |
ScholarBank@NUS |
| topic |
2 [3 (3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)propyl]isoindoline 1,3 dione 4 (2,6 dichlorobenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 isopropylbenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 nitrobenzyl) 2h pyrido [3,2 b][1,4]oxazin 3(4h) one 4 (cyclohexylmethyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)methyl]benzonitrile 4 [(6,6 dimethyl 4 phenyl 5,6 dihydro 4h 1,2 oxazin 3 yl)methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [4 (tert butyl)benzyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [[4 (4 chlorophenyl) 6,6 dimethyl 5,6 dihydro 4h 1,2 oxazin 3 yl]methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4' [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3H) yl)methyl] [1,10 biphenyl] 2 carbonitrile antineoplastic agent DNA immunoglobulin enhancer binding protein liver protective agent luciferase transcription factor RelA unclassified drug animal experiment animal model animal tissue antiproliferative activity apoptosis Article cancer inhibition cell viability computer model controlled study dose response down regulation drug effect drug efficacy drug identification drug potency drug synthesis female gene expression regulation HCCLM3 cell line Hep-G2 cell line Huh-7 cell line IC50 liver cell carcinoma luciferase gene molecularly targeted therapy mouse nonhuman pharmacological parameters protein DNA binding protein expression protein phosphorylation time dependence tumor volume |
| spellingShingle |
2 [3 (3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)propyl]isoindoline 1,3 dione 4 (2,6 dichlorobenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 isopropylbenzyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 (4 nitrobenzyl) 2h pyrido [3,2 b][1,4]oxazin 3(4h) one 4 (cyclohexylmethyl) 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3h) yl)methyl]benzonitrile 4 [(6,6 dimethyl 4 phenyl 5,6 dihydro 4h 1,2 oxazin 3 yl)methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [4 (tert butyl)benzyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4 [[4 (4 chlorophenyl) 6,6 dimethyl 5,6 dihydro 4h 1,2 oxazin 3 yl]methyl] 2h pyrido[3,2 b][1,4]oxazin 3(4h) one 4' [(3 oxo 2h pyrido[3,2 b][1,4]oxazin 4(3H) yl)methyl] [1,10 biphenyl] 2 carbonitrile antineoplastic agent DNA immunoglobulin enhancer binding protein liver protective agent luciferase transcription factor RelA unclassified drug animal experiment animal model animal tissue antiproliferative activity apoptosis Article cancer inhibition cell viability computer model controlled study dose response down regulation drug effect drug efficacy drug identification drug potency drug synthesis female gene expression regulation HCCLM3 cell line Hep-G2 cell line Huh-7 cell line IC50 liver cell carcinoma luciferase gene molecularly targeted therapy mouse nonhuman pharmacological parameters protein DNA binding protein expression protein phosphorylation time dependence tumor volume Mohan, C.D Bharathkumar, H Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, S Shanmugam, M.K Chinnathambi, A Alharbi, S.A Alahmadi, T.A Bhattacharjee, A Lobie, P.E Deivasigamani, A Hui, K.M Sethi, G Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, K.S Kumar, A.P N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| description |
10.3389/fphar.2018.01125 |
| author2 |
DEPT OF PHARMACOLOGY |
| author_facet |
DEPT OF PHARMACOLOGY Mohan, C.D Bharathkumar, H Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, S Shanmugam, M.K Chinnathambi, A Alharbi, S.A Alahmadi, T.A Bhattacharjee, A Lobie, P.E Deivasigamani, A Hui, K.M Sethi, G Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, K.S Kumar, A.P |
| format |
Article |
| author |
Mohan, C.D Bharathkumar, H Dukanya, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, S Shanmugam, M.K Chinnathambi, A Alharbi, S.A Alahmadi, T.A Bhattacharjee, A Lobie, P.E Deivasigamani, A Hui, K.M Sethi, G Basappa, Laboratory of Chemical Biology, Department of Chemistry, Bangalore University, Bangalore, India, Department of Studies in Organic Chemistry, University of Mysore, Mysore, India Rangappa, K.S Kumar, A.P |
| author_sort |
Mohan, C.D |
| title |
N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| title_short |
N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| title_full |
N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| title_fullStr |
N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| title_full_unstemmed |
N-substituted pyrido-1,4-Oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting NF-?B signaling pathway |
| title_sort |
n-substituted pyrido-1,4-oxazin-3-ones induce apoptosis of hepatocellular carcinoma cells by targeting nf-?b signaling pathway |
| publishDate |
2020 |
| url |
https://scholarbank.nus.edu.sg/handle/10635/181171 |
| _version_ |
1781792444849848320 |