ClC-7 expression levels critically regulate bone turnover, but not gastric acid secretion

• Main Authors: Supanchart C., Wartosch L., Schlack C., Kuhnisch J., Felsenberg D., Fuhrmann J.C., de Vernejoul M.-C., Jentsch T.J., Kornak U.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84886859886&partnerID=40&md5=75744fda9332ed7c9e63c982dd63d06d; http://cmuir.cmu.ac.th/handle/6653943832/1179
• Institution: Chiang Mai University

Mutations in the 2Cl-/1H+-exchanger ClC-7 impair osteoclast function and cause different types of osteoclast-rich osteopetrosis. However, it is unknown to what extent ClC-7 function has to be reduced to become rate-limiting for bone resorption. In osteoclasts from osteopetrosis patients expression o...