Engagement of CD147 molecule-induced cell aggregation through the activation of protein kinases and reorganization of the cytoskeleton

• Main Authors: Khunkeawla P., Moonsom S., Staffler G., Kongtawelert P., Kasinrerk W.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035005551&partnerID=40&md5=7d5aea3477e7ca4e0976db09594d824f; http://www.ncbi.nlm.nih.gov/pubmed/11402500; http://cmuir.cmu.ac.th/handle/6653943832/1902

CD147 is a broadly expressed cell surface molecule of the immunoglobulin superfamily whose expression is up-regulated upon T cell activation. Engagement of CD147 by CD147 monoclonal antibodies (mAbs) has been shown to induce homotypic aggregation of U937 cells. To study intracellular signal transduc...