Analysis of β-thalassemia mutations in northern Thailand using an automated fluorescence DNA sequencing technique

• المؤلفون الرئيسيون: Sirichotiyakul S., Saetung R., Sanguansermsri T.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الوصول للمادة أونلاين: http://www.scopus.com/inward/record.url?eid=2-s2.0-0038585087&partnerID=40&md5=344940f77d9d465c2c7acfc47528a5c5; http://cmuir.cmu.ac.th/handle/6653943832/3181
• المؤسسة: Chiang Mai University

A total of 218 β-thalassemia (thal) genes from 109 β-thal major patients were characterized using an automated fluorescence DNA sequencing technique. Eight different mutations were identified in all 218 alleles (100%). Four common mutations accounted for 96.8% [49.5% were codons 41/42 (-TTCT), 34.4%...