Involvement of the P2X<inf>7</inf>purinergic receptor and c-Jun N-terminal and extracellular signal-regulated kinases in cyclooxygenase-2 and prostaglandin E<inf>2</inf>induction by LL-37

• Main Authors: Pareena Chotjumlong, Jan G. Bolscher, Kamran Nazmi, Vichai Reutrakul, Chayarop Supanchart, Worakanya Buranaphatthana, Suttichai Krisanaprakornkit
• 格式: 雜誌
• 出版: 2018
• 主題: Medicine
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84872276132&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/52948

Periodontal disease is caused by microorganisms and host-derived inflammation involving increased cyclooxygenase-2 (COX-2) expression and prostaglandin E2(PGE2) production. We previously demonstrated that human β-defensin-3 induces COX-2 and PGE2in human gingival fibroblasts (HGFs). We, therefore, a...