Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds

• المؤلفون الرئيسيون: Jiradanai Sarasamkan, Matthias Scheunemann, Nattayaporn Apaijai, Siripong Palee, Warisara Parichatikanond, Kuntarat Arunrungvichian, Steffen Fischer, Siriporn Chattipakorn, Winnie Deuther-Conrad, Gerrit Schüürmann, Peter Brust, Opa Vajragupta
• التنسيق: دورية
• منشور في: 2018
• الموضوعات: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• الوصول للمادة أونلاين: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84991574459&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55132

© 2016 American Chemical Society. The novel quinuclidine anti-1,2,3-triazole derivatives T1-T6 were designed based on the structure of QND8. The binding studies revealed that the stereochemistry at the C3 position of the quinuclidine scaffold plays an important role in the nAChR subtype selectivity....