FGF21 improves cognition by restored synaptic plasticity, dendritic spine density, brain mitochondrial function and cell apoptosis in obese-insulin resistant male rats

• Main Authors: Piangkwan Sa-nguanmoo, Pongpan Tanajak, Sasiwan Kerdphoo, Pattarapong Satjaritanun, Xiaojie Wang, Guang Liang, Xiaokun Li, Chao Jiang, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C. Chattipakorn
• 格式: 雜誌
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Neuroscience
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84983605315&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/55151

© 2016 Elsevier Inc. Fibroblast growth factor 21 (FGF21) is an endocrine hormone which exerts beneficial effects on metabolic regulation in obese and diabetic models. However, the effect of FGF21 on cognition in obese-insulin resistant rats has not been investigated. We hypothesized that FGF21 preve...