Co-activation of WT1 and AP-1 proteins on WT1 gene promoter to induce WT1 gene expression in K562 cells

• Main Authors: Songyot Anuchapreeda, Methee Rungrojsakul, Singkome Tima, Sawitree Chiampanichayakul, Sheryl R. Krig
• 格式: 雜誌
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology
• 在線閱讀: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056238200&origin=inward; http://cmuir.cmu.ac.th/jspui/handle/6653943832/62910

© 2018 Earlier studies have revealed one function of the inhibitory mechanism of curcumin. Activating PKCα induces WT1 gene expression via signalling through downstream JNK and c-JUN. In the present study, the effect of c-JUN/AP-1 binding and transcriptional regulation of the WT1 gene promoter was i...