Impaired bone formation and osteopenia in heterozygous β^iVSII-654knockin thalassemic mice

• Main Authors: Kanogwun Thongchote, Saovaros Svasti, Mayurachat Sa-Ardrit, Nateetip Krishnamra, Suthat Fucharoen, Narattaphol Charoenphandhu
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Health Professions; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/11517

β-thalassemia caused by the C→T mutation at nucleotide 654 of the intron 2 (β IVSII-654 ) results in aberrant splicing of β-globin RNA, leading to an almost absence of β-globin synthesis. Although trabecular and cortical bone loss was previously reported in β-thalassemic mice with deletion of β-glob...