Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR
The diagnostic utility of the Standard Diagnostics . Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) ≥0.75], the assay demonstrated limited diagnostic capacity...
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th-mahidol.142782018-06-11T12:06:01Z Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR Ampai Tanganuchitcharnchai Lee Smythe Michael Dohnt Rudy Hartskeerl Manivanh Vongsouvath Viengmone Davong Olay Lattana Paul N. Newton Stuart D. Blacksell Mahidol University World Health Organization, Australia Royal Tropical Institute - KIT Mahosot Hospital University of Oxford Immunology and Microbiology Medicine The diagnostic utility of the Standard Diagnostics . Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) ≥0.75], the assay demonstrated limited diagnostic capacity with a sensitivity of 95% and a specificity of 41% compared with the . Leptospira microscopic agglutination test, which is the serological gold standard. However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%). © 2012 Royal Society of Tropical Medicine and Hygiene. 2018-06-11T04:52:02Z 2018-06-11T04:52:02Z 2012-09-01 Article Transactions of the Royal Society of Tropical Medicine and Hygiene. Vol.106, No.9 (2012), 563-566 10.1016/j.trstmh.2012.06.002 18783503 00359203 2-s2.0-84864819561 https://repository.li.mahidol.ac.th/handle/123456789/14278 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84864819561&origin=inward |
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Immunology and Microbiology Medicine Ampai Tanganuchitcharnchai Lee Smythe Michael Dohnt Rudy Hartskeerl Manivanh Vongsouvath Viengmone Davong Olay Lattana Paul N. Newton Stuart D. Blacksell Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
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The diagnostic utility of the Standard Diagnostics . Leptospira IgM ELISA for detection of acute leptospirosis was assessed in febrile adults admitted in Vientiane, Laos. Using the cut-off suggested by the manufacturer [optical density (OD) ≥0.75], the assay demonstrated limited diagnostic capacity with a sensitivity of 95% and a specificity of 41% compared with the . Leptospira microscopic agglutination test, which is the serological gold standard. However, re-evaluation of the diagnostic cut-off to an OD of 1.7 demonstrated improved diagnostic accuracy overall (sensitivity 70%; specificity 78%). © 2012 Royal Society of Tropical Medicine and Hygiene. |
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Mahidol University |
author_facet |
Mahidol University Ampai Tanganuchitcharnchai Lee Smythe Michael Dohnt Rudy Hartskeerl Manivanh Vongsouvath Viengmone Davong Olay Lattana Paul N. Newton Stuart D. Blacksell |
format |
Article |
author |
Ampai Tanganuchitcharnchai Lee Smythe Michael Dohnt Rudy Hartskeerl Manivanh Vongsouvath Viengmone Davong Olay Lattana Paul N. Newton Stuart D. Blacksell |
author_sort |
Ampai Tanganuchitcharnchai |
title |
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
title_short |
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
title_full |
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
title_fullStr |
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
title_full_unstemmed |
Evaluation of the Standard Diagnostics Leptospira IgM ELISA for diagnosis of acute leptospirosis in Lao PDR |
title_sort |
evaluation of the standard diagnostics leptospira igm elisa for diagnosis of acute leptospirosis in lao pdr |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/14278 |
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1763494400259784704 |