Combretastatins D-3 and D-4, new macrocyclic lactones from Getonia floribunda

• Main Authors: Namphung Vongvanich, Prasat Kittakoop, Panarat Charoenchai, Sutichai Intamas, Kannawat Danwisetkanjana, Yodhathai Thebtaranonth
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16380

Chemical investigation of biologically active compounds of Getonia floribunda led to the isolation of two new macrocyclic lactones, combretastatins D-3 (1) and D-4 (2). The structures of these compounds were confirmed by spectroscopic analyses. Combretastatin D-3 (1) exhibited cytotoxicity towards t...