IFN-γ at the site of infection determines rate of clearance of infection in cryptococcal meningitis

• Main Authors: Asna A. Siddiqui, Annemarie E. Brouwer, Vannaporn Wuthiekanun, Shabbar Jaffar, Robin Shattock, Diane Irving, Joanna Sheldon, Wirongrong Chierakul, Sharon Peacock, Nicholas Day, Nicholas J. White, Thomas S. Harrison
• Other Authors: St George's University of London
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/16609
• Institution: Mahidol University

In animal models, immunity to cryptococcal infection, as in many chronic fungal and bacterial infections, is associated with a granulomatous inflammatory response, intact cell-mediated immunity, and a Th1 pattern of cytokine release. To examine the correlates of human immunity to cryptococcal infect...