Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells

• Main Authors: Ko Ichi Kawahara, Teruto Hashiguchi, Kiyoshi Kikuchi, Salunya Tancharoen, Naoki Miura, Takashi Ito, Yoko Oyama, Yuko Nawa, Kamal K. Biswas, Xiaojie Meng, Yoko Morimoto, Binita Shrestha, Hisayo Sameshima, Ikuro Maruyama
• Other Authors: Kagoshima University Faculty of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/18814
• Institution: Mahidol University

High mobility group box 1 (HMGB1) is a nonhistone nuclear protein which is released from the nucleus of activated macrophages into the extracellular space in response to stimuli such as endotoxin or necrosis. The HMGB1 functions as a potent proinflammatory cytokine in the extracellular spaces. Recen...