Cytotoxic Coumarins from Mammea harmandii

• Main Authors: Vichai Reutrakul, Pornsiri Leewanich, Patoomratana Tuchinda, Manat Pohmakotr, Thaworn Jaipetch, Samaisukh Sophasan, Thawatchai Santisuk
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/20681

Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3-11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their st...