Targeting the JNK MAPK cascade for inhibition: Basic science and therapeutic potential

• Main Authors: Marie A. Bogoyevitch, Ingrid Boehm, Aaron Oakley, Albert J. Ketterman, Renae K. Barr
• Other Authors: University of Western Australia
• Format: Conference or Workshop Item
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/21218
• Institution: Mahidol University

The c-Jun N-terminal protein kinases (JNKs) form one subfamily of the mitogen-activated protein kinase (MAPK) group of serine/threonine protein kinases. The JNKs were first identified by their activation in response to a variety of extracellular stresses and their ability to phosphorylate the N-term...