Total synthesis of racemosol and de-O-methylracemosol, potent cyclooxygenase (COX) inhibitors and antimalarial agents
The total synthesis of antimalarial and cyclooxygenase inhibitors, racemosol and de-O-methylracemosol, is described. The key steps involved the lateral lithiation reaction of ortho-methyl tolulate and the pyran formation via a tandem demethylation-cyclization reaction. © 2005 Elsevier Ltd. All right...
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| Main Authors: | , , |
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| Format: | Article |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/23097 |
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| Institution: | Mahidol University |