Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis
The objective of this study was to determine factors associated with pyridostigmine therapy in patients with ocular myasthenia gravis (OMG). This retrospective study included eighty - five patients with OMG who have been treated with pyridostigmine. Patients were excluded if they were diagnosed as g...
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th-mahidol.245702018-08-24T09:08:51Z Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis Niphon Chirapapaisan Supinda Tanormrod Wanicha Chuenkongkaew Mahidol University Immunology and Microbiology Medicine The objective of this study was to determine factors associated with pyridostigmine therapy in patients with ocular myasthenia gravis (OMG). This retrospective study included eighty - five patients with OMG who have been treated with pyridostigmine. Patients were excluded if they were diagnosed as generalized myasthenia gravis within a month after diagnosis or were treated with other medications. Forty-two patients responded to pyridostigmine and 43 patients did not. There were no significant differences in gender, age, the duration of symptoms before treatment, the dosage of pyridostigmine, and the initial presentations of ptosis or diplopia between the two groups. However, an initial presentation of concurrent ptosis and diplopia and the presence of systemic involvement after follow up were significant factors associated with an insensitivity to pyridostigmine in patients with OMG (p = 0.001 and p = 0.01, respectively). Determining these factors could help predict the pyridostigmine response in patients with OMG. 2018-08-24T01:54:08Z 2018-08-24T01:54:08Z 2007-03-01 Article Asian Pacific Journal of Allergy and Immunology. Vol.25, No.1 (2007), 13-16 0125877X 2-s2.0-34250886242 https://repository.li.mahidol.ac.th/handle/123456789/24570 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=34250886242&origin=inward |
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Immunology and Microbiology Medicine Niphon Chirapapaisan Supinda Tanormrod Wanicha Chuenkongkaew Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
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The objective of this study was to determine factors associated with pyridostigmine therapy in patients with ocular myasthenia gravis (OMG). This retrospective study included eighty - five patients with OMG who have been treated with pyridostigmine. Patients were excluded if they were diagnosed as generalized myasthenia gravis within a month after diagnosis or were treated with other medications. Forty-two patients responded to pyridostigmine and 43 patients did not. There were no significant differences in gender, age, the duration of symptoms before treatment, the dosage of pyridostigmine, and the initial presentations of ptosis or diplopia between the two groups. However, an initial presentation of concurrent ptosis and diplopia and the presence of systemic involvement after follow up were significant factors associated with an insensitivity to pyridostigmine in patients with OMG (p = 0.001 and p = 0.01, respectively). Determining these factors could help predict the pyridostigmine response in patients with OMG. |
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Mahidol University |
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Mahidol University Niphon Chirapapaisan Supinda Tanormrod Wanicha Chuenkongkaew |
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Article |
author |
Niphon Chirapapaisan Supinda Tanormrod Wanicha Chuenkongkaew |
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Niphon Chirapapaisan |
title |
Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
title_short |
Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
title_full |
Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
title_fullStr |
Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
title_full_unstemmed |
Factors associated with insensitivity to pyridostigmine therapy in Thai patiens with ocular myasthenia gravis |
title_sort |
factors associated with insensitivity to pyridostigmine therapy in thai patiens with ocular myasthenia gravis |
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2018 |
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https://repository.li.mahidol.ac.th/handle/123456789/24570 |
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1763487815810678784 |