Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced cell death in ischemic neuronal injury in PC12 cells

• Main Authors: Kiyoshi Kikuchi, Ko ichi Kawahara, Kamal Krishna Biswas, Takashi Ito, Salunya Tancharoen, Yoko Morimoto, Fumiyo Matsuda, Yoko Oyama, Kazunori Takenouchi, Naoki Miura, Noboru Arimura, Yuko Nawa, Xiaojie Meng, Binita Shrestha, Shinichiro Arimura, Masahiro Iwata, Kentaro Mera, Hisayo Sameshima, Yoshiko Ohno, Ryuichi Maenosono, Yoshihiro Yoshida, Yutaka Tajima, Hisaaki Uchikado, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Teruto Hashiguchi, Ikuro Maruyama
• Other Authors: Division of Laboratory and Vascular Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27175
• Institution: Mahidol University

High mobility group box-1 (HMGB1), a non-histone DNA-binding protein, is massively released into the extracellular space from neuronal cells after ischemic insult and exacerbates brain tissue damage in rats. Minocycline is a semisynthetic second-generation tetracycline antibiotic which has recently...