The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells

• Main Authors: Kiyoshi Kikuchi, Ko Ichi Kawahara, Salunya Tancharoen, Fumiyo Matsuda, Yoko Morimoto, Takashi Ito, Kamal Krishna Biswas, Kazunori Takenouchi, Naoki Miura, Yoko Oyama, Yuko Nawa, Noboru Arimura, Masahiro Iwata, Yutaka Tajima, Terukazu Kuramoto, Kenji Nakayama, Minoru Shigemori, Yoshihiro Yoshida, Teruto Hashiguchi, Ikuro Maruyama
• Other Authors: Kagoshima University Faculty of Medicine
• Format: Article
• Published: 2018
• Subjects: Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/27216
• Institution: Mahidol University

Edaravone, a potent free radical scavenger, is clinically used for the treatment of cerebral infarction in Japan. Here, we examined the effects of edaravone on the dynamics of high-mobility group box-1 (HMGB1), which is a key mediator of ischemic-induced brain damage, during a 48-h postischemia/ rep...