Severe malaria is associated with a deficiency of von Willebrand factor cleaving protease, ADAMTS13

• Main Authors: Ester C. Löwenberg, Prakaykaew Charunwatthana, Sophie Cohen, Bert Jan Van Den Born, Joost C.M. Meijers, Emran B. Yunus, Mahtab U. Hassan, Gofranul Hoque, Richard J. Maude, Forradee Nuchsongsin, Marcel Levi, Arjen M. Dondorp
• Other Authors: Academic Medical Centre, University of Amsterdam
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/29883
• Institution: Mahidol University

Severe falciparum malaria remains a major killer in tropical countries. Central in the pathophysiology is mechanical obstruction in the microcirculation caused by cytoadherence and sequestration of parasitized erythrocytes. However, the pathogenesis of many features complicating severe malaria, incl...