Using a web-based application to define the accuracy of diagnostic tests when the gold standard is imperfect

• Main Authors: Cherry Lim, Prapass Wannapinij, Lisa White, Nicholas P.J. Day, Ben S. Cooper, Sharon J. Peacock, Direk Limmathurotsakul
• Other Authors: Mahidol University
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/30952

Background: Estimates of the sensitivity and specificity for new diagnostic tests based on evaluation against a known gold standard are imprecise when the accuracy of the gold standard is imperfect. Bayesian latent class models (LCMs) can be helpful under these circumstances, but the necessary analy...