Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS

• Main Authors: Kongtana Trakarnsanga, Marieangela C. Wilson, Rebecca E. Griffiths, Ashley M. Toye, Lee Carpenter, Kate J. Heesom, Steve F. Parsons, David J. Anstee, Jan Frayne
• Other Authors: University of Bristol
• Format: Article
• Published: 2018
• Subjects: Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/33005
• Institution: Mahidol University

Induced pluripotent stem cells (iPSC) are an attractive progenitor source for the generation of in vitro blood products. However, before iPSC-derived erythroid cells can be considered for therapeutic use their similarity to adult erythroid cells must be confirmed. We have analysed the proteome of er...