A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

• Main Authors: Jonathon L. Burman, Leslie S. Itsara, Ernst Bernhard Kayser, Wichit Suthammarak, Adrienne M. Wang, Matt Kaeberlein, Margaret M. Sedensky, Philip G. Morgan, Leo J. Pallanck
• 其他作者: University of Washington, Seattle
• 格式: Article
• 出版: 2018
• 主題: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Neuroscience
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/33459
• 機構: Mahidol University

© 2014, Company of Biologists Ltd. All rights reserved. Mutations affecting mitochondrial complex I, a multi-subunit assembly that couples electron transfer to proton pumping, are the most frequent cause of heritable mitochondrial diseases. However, the mechanisms by which complex I dysfunction resu...