Increased intra- and extracellular granzyme expression in patients with tuberculosis

• Main Authors: M. Isabel Garcia-Laorden, Dana C. Blok, Liesbeth M. Kager, Arie J. Hoogendijk, Gerard J. Van Mierlo, Ivar O. Lede, Wahid Rahman, Rumana Afroz, Aniruddha Ghose, Caroline E. Visser, Abu Shahed Md Zahed, Md Anwar Husain, Khan Mashrequl Alam, Pravat Chandra Barua, Mahtabuddin Hassan, Ahmed Hossain, Md Abu Tayab, Nick Day, Arjen M. Dondorp, Alex F. De Vos, Tom Van Der Poll
• Other Authors: Academic Medical Centre, University of Amsterdam
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/36083
• Institution: Mahidol University

© 2015 Elsevier Ltd. Summary Tuberculosis (TB) is an important cause of morbidity and mortality worldwide. Granzymes (gzms) are proteases mainly found in cytotoxic lymphocytes, but also extracellularly. While the role of gzms in target cell death has been widely characterized, considerable evidence...