Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women
Purpose: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (...
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th-mahidol.881592023-07-31T01:02:13Z Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women da Silva Rodrigues G. Mahidol University Medicine Purpose: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. Methods: Eighteen women (AARLow: lower age acceleration residual, n = 10; AARHigh: higher age acceleration residual, n = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina’s Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting p <.05. Results: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AARLow group (PRE: −2.3 ± 3.2 to POST: −2.3 ± 3.6). However, the AARHigh group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, p =.01; time effect, p =.31; group vs. time effect, p =.005). Conclusion: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age. 2023-07-30T18:02:13Z 2023-07-30T18:02:13Z 2023-01-01 Article Research Quarterly for Exercise and Sport (2023) 10.1080/02701367.2023.2228388 21683824 02701367 2-s2.0-85165426646 https://repository.li.mahidol.ac.th/handle/123456789/88159 SCOPUS |
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Mahidol University |
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Mahidol University Library |
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Asia |
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Thailand Thailand |
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Mahidol University Library |
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Mahidol University Institutional Repository |
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Medicine |
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Medicine da Silva Rodrigues G. Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| description |
Purpose: The acceleration of epigenetic age is a predictor of mortality and contributes to the increase in chronic diseases. Adherence to a healthy lifestyle is a strategy to reduce epigenetic age. The present study aimed to determine whether eight weeks of combined (aerobic and strength) training (CT) can influence the epigenetic age of women between 50 and 70 years old and the differences in sites and methylated regions. Methods: Eighteen women (AARLow: lower age acceleration residual, n = 10; AARHigh: higher age acceleration residual, n = 8) participated in a combined exercise training program (60 minutes, 3× a week) for eight weeks. DNA was extracted from whole blood using the salting out technique. DNA methylation was performed using the array technique (Illumina’s Infinium Methylation BeadChip 850k). We used the DNA Methylation Age Calculator platform to calculate the biological epigenetic age. Two-way ANOVA followed by FISHER LSD posthoc was Applied, adopting p <.05. Results: After eight weeks of CT, there were no changes to the epigenetic age acceleration for the AARLow group (PRE: −2.3 ± 3.2 to POST: −2.3 ± 3.6). However, the AARHigh group significantly decreased the age acceleration (PRE: 3.6 ± 2.6 to POST: 2.2 ± 2.7) (group effect, p =.01; time effect, p =.31; group vs. time effect, p =.005). Conclusion: CT for eight weeks benefits the epigenetic clock of women with the most accelerated age. |
| author2 |
Mahidol University |
| author_facet |
Mahidol University da Silva Rodrigues G. |
| format |
Article |
| author |
da Silva Rodrigues G. |
| author_sort |
da Silva Rodrigues G. |
| title |
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| title_short |
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| title_full |
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| title_fullStr |
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| title_full_unstemmed |
Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women |
| title_sort |
eight weeks of physical training decreases 2 years of dna methylation age of sedentary women |
| publishDate |
2023 |
| url |
https://repository.li.mahidol.ac.th/handle/123456789/88159 |
| _version_ |
1781415329616887808 |