Pathology of the Lung Allograft
Recent advances in immunosuppressive medications, clinical immunology, patient selection, and surgical techniques have improved the outcome of lung transplants as a group, yet the overall survival is still the lowest among all solid organ allografts. Pathology has played a primordial role in this pr...
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th-mahidol.900232023-09-16T01:02:03Z Pathology of the Lung Allograft Sathirareuangchai S. Mahidol University Medicine Recent advances in immunosuppressive medications, clinical immunology, patient selection, and surgical techniques have improved the outcome of lung transplants as a group, yet the overall survival is still the lowest among all solid organ allografts. Pathology has played a primordial role in this process by the recognition and understanding of the multifactorial complications that may affect lung allografts and decrease both organ and patient survival. In this chapter, we present the latest understanding and classification of the most common complication of lung allografts, including primary allograft dysfunction, acute cellular vs. antibody-mediated rejection, obstructive vs. restrictive chronic allograft injury, chronic allograft vasculopathy, infections of the transplanted lung, and special topics that include recurrent diseases in the lung transplant and posttransplant lymphoproliferative disorders. Classifications followed the International Society of Heart and Lung Transplant guidelines for both cellular and antibody-mediated rejection. We also refer to selected articles published in the medical literature and mention, when appropriate, our own experience in dealing with lung allograft biopsies and resection specimens. 2023-09-15T18:02:03Z 2023-09-15T18:02:03Z 2023-01-01 Book Chapter The Thorax: Medical, Radiological, and Pathological Assessment (2023) , 907-920 10.1007/978-3-031-21040-2_27 2-s2.0-85170156269 https://repository.li.mahidol.ac.th/handle/123456789/90023 SCOPUS |
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Recent advances in immunosuppressive medications, clinical immunology, patient selection, and surgical techniques have improved the outcome of lung transplants as a group, yet the overall survival is still the lowest among all solid organ allografts. Pathology has played a primordial role in this process by the recognition and understanding of the multifactorial complications that may affect lung allografts and decrease both organ and patient survival. In this chapter, we present the latest understanding and classification of the most common complication of lung allografts, including primary allograft dysfunction, acute cellular vs. antibody-mediated rejection, obstructive vs. restrictive chronic allograft injury, chronic allograft vasculopathy, infections of the transplanted lung, and special topics that include recurrent diseases in the lung transplant and posttransplant lymphoproliferative disorders. Classifications followed the International Society of Heart and Lung Transplant guidelines for both cellular and antibody-mediated rejection. We also refer to selected articles published in the medical literature and mention, when appropriate, our own experience in dealing with lung allograft biopsies and resection specimens. |
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Book Chapter |
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Sathirareuangchai S. |
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Sathirareuangchai S. |
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Pathology of the Lung Allograft |
title_short |
Pathology of the Lung Allograft |
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Pathology of the Lung Allograft |
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Pathology of the Lung Allograft |
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Pathology of the Lung Allograft |
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pathology of the lung allograft |
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2023 |
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https://repository.li.mahidol.ac.th/handle/123456789/90023 |
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